Application of IL-32 in regulation and control of mesenchymal stem cell osteogenic differentiation

The invention relates to application of IL-32 in regulation and control of mesenchymal stem cell osteogenic differentiation. According to the application, the function of the IL-32 for regulating and controlling the osteogenic differentiation of the mesenchymal stem cells and the possible action mec...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG XIARU, WANG YANG, ZHANG YI, LI XUE, LIU YUANLIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to application of IL-32 in regulation and control of mesenchymal stem cell osteogenic differentiation. According to the application, the function of the IL-32 for regulating and controlling the osteogenic differentiation of the mesenchymal stem cells and the possible action mechanism of the IL-32 are researched, and the possibility is provided for taking the IL-32 as a product for regulating and controlling the osteogenic differentiation of the mesenchymal stem cells. By constructing hUC-MSC capable of stably overexpressing IL-32 and researching biological characteristics of the hUC-MSC, it is found that compared with normal MSC, the osteogenic differentiation function of the IL-32 is affected, it is indicated that the osteogenic differentiation function of the hUC-MSC can be effectively regulated and controlled by the IL-32, osteogenic differentiation of the hUC-MSC can be known more clearly, and a guiding effect is achieved for clinical treatment of osteoporosis. IL-32在调控间充质干细胞成骨分化中的用途