Polypeptide compound aiming at SORT1 and drug conjugate thereof

The present invention relates to a targeting peptide specifically targeting a Sortiin/SORT1 protein, and a targeting peptide-drug conjugate comprising the targeting peptide. The targeting peptide is linear peptide or cyclic peptide containing non-natural chemical modification, and the half-life period of the targeting peptide-drug conjugate can be prolonged, and the stability of the targeting peptide-drug conjugate can be improved. The targeting peptide-drug conjugate can be specifically combined with target protein Sortiin/SORT1 with high affinity, so that tumors expressing Sortiin/SORT1 are efficiently killed, and a novel anti-tumor targeting drug is provided for the field of tumor treatment. 一种特异性靶向Sortilin/SORT1蛋白的靶向肽，以及包含所述靶向肽的靶向肽-药物偶联物。该靶向肽为含非天然化学修饰的线性肽或环肽，可以改善靶向肽-药物偶联物的半衰期并提高其稳定性。靶向肽-药物偶联物能够以高亲和力特异性结合靶蛋白Sortilin/SORT1，从而高效杀伤表达Sortilin/SORT1的肿瘤，为肿瘤治疗领域提供了一种新型抗肿瘤靶向药。