Tetracycline compound with ninth site containing Mannich base as well as preparation method and application of tetracycline compound

The invention discloses a tetracycline compound containing Mannich base at the ninth site and a preparation method and application thereof. The preparation method disclosed by the invention comprises the following step: in a solvent, carrying out a reaction as shown in the specification on a compound as shown in a formula I-A, a compound as shown in a formula SM-1 and formaldehyde to obtain a compound as shown in a formula I. The method is simple in step, mild in reaction condition and high in operability, and a product with relatively high yield and purity can be obtained through simple purification. The compound shown in the formula I can be used for treating diseases caused by bacterial, virus or microbial infection. # imgabs0 # 本发明公开了9位含曼尼希碱的四环素类化合物及其制备方法和应用。本发明公开的制备方法，包含以下步骤：在溶剂中，将如式I-A所示的化合物、如式SM-1所示的化合物和甲醛进行如下所示的反应，得到如式Ι所示的化合物。该方法步骤简单、反应条件温和、可操作性强、经简单纯化即可得到较高收率和纯度的产品。该如式Ι所示的化合物可用于治疗由细菌、病毒或微生物感染引起的疾病。#imgabs0#