Self-foaming expansion composite bone cement with high drug release property and preparation method of self-foaming expansion composite bone cement

The invention discloses self-foaming expansion composite bone cement with high drug release property and a preparation method thereof, and belongs to the technical field of biomedical material preparation methods. The self-foaming expansion composite bone cement with high drug release property is prepared from a solid-phase component and a liquid-phase component, the ratio of the solid phase component to the liquid phase component is 1g: (0.36-0.44) ml; the solid phase component is prepared from the following components in percentage by mass: 60%-72.7% of polymethyl methacrylate, 4%-12% of citric acid, 4%-12% of sodium bicarbonate, 11%-13% of zirconium dioxide, 0.5%-0.7% of benzoyl peroxide, 0.9%-1% of gentamicin sulfate and the balance of vancomycin; and the liquid phase component is a mixed solution of methyl methacrylate and N, N-dimethyl p-toluidine in a mass ratio of (97.5-98.5): (1.5-2.5). The self-foaming expansion composite bone cement prepared by the invention has good mechanical properties and extre