CSF1R receptor and use of inhibitor thereof

The invention relates to the field of biological medicine, in particular to CSF1R and new application of an inhibitor of the CSF1R. The invention discloses application of CSF1R as a target spot in screening intervention drugs of anesthetics such as a GABAA receptor, an NMDA receptor and a beta2A receptor. The invention further discloses an application of the CSF1R inhibitor, namely the PLX5622, in preparation of intervention drugs of GABAA (gamma-aminobutyric acid), NMDA (N-methyldiethanolamine) and beta2A receptor anesthetics at the same time. According to the invention, the consciousness loss duration induced by GABAA, NMDA and beta2A receptor anesthetics can be obviously shortened. 本发明涉及生物医药领域，特别涉及CSF1R及其抑制剂的新用途。本发明公开了CSF1R作为靶点在筛选GABAA受体、NMDA受体、β2A受体类麻醉剂的干预药物中的应用。本发明还同时公开了CSF1R抑制剂---PLX5622在制备GABAA、NMDA、β2A受体类麻醉剂的干预药物中的应用；本发明能显著缩短GABAA、NMDA、β2A受体类麻醉剂诱导的意识丧失时长。