Application of CD177 anti-inflammatory neutrophil in treatment of cerebral arterial thrombosis

The invention provides an application of CD177 anti-inflammatory neutrophil in treatment of cerebral arterial thrombosis, in particular provides an application of CD177 positive neutrophil in preparation of a medicine for treating cerebral arterial thrombosis, and provides a method for treating cere...

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Bibliographische Detailangaben
Hauptverfasser: YU WEIFENG, ZHANG YUEMAN, CHEN WEIJIE, LI PEIYING, CHEN CHEN, LI YAN, HUANG TINGTING, XIE WANQING, GUO YUNLU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides an application of CD177 anti-inflammatory neutrophil in treatment of cerebral arterial thrombosis, in particular provides an application of CD177 positive neutrophil in preparation of a medicine for treating cerebral arterial thrombosis, and provides a method for treating cerebral arterial thrombosis based on CD177 positive neutrophil intervention. By constructing a mouse cerebral arterial thrombosis model, it is verified that the CD177 positive neutrophil reduces the mouse cerebral infarction volume, reduces the neuroinflammation level in the brain and relieves blood-brain barrier damage by inhibiting transformation of microglial cells to pro-inflammatory phenotypes, so that cerebral arterial thrombosis can be effectively treated, and the CD177 positive neutrophil can be used for treating cerebral arterial thrombosis. A new thought is provided for the neutrophil therapy of cerebral apoplexy. 本发明提供了CD177抑炎型中性粒细胞对缺血性脑卒中治疗的应用,具体地,提供了一种CD177阳性中性粒细胞在制备用于治疗缺血性脑卒中的药物中的用途,并提供了一种基于CD177阳性中性粒细胞干