C-Met protein binding peptide complexes

[Problem] To provide a peptide complex that binds to c-Met protein. [Solution] A peptide complex containing a peptide A which is a peptide comprising the amino acid sequence depicted in X1-X2-X3-V-S-X4-D-X5-D-X6-P-R-W-X7-MeC (SEQ ID NO: 1) or an amino acid sequence obtained by substituting, deleting...

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Hauptverfasser: TAKUWA MASANORI, EHARA TAKESHI, SUZUKI YOSHINORI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:[Problem] To provide a peptide complex that binds to c-Met protein. [Solution] A peptide complex containing a peptide A which is a peptide comprising the amino acid sequence depicted in X1-X2-X3-V-S-X4-D-X5-D-X6-P-R-W-X7-MeC (SEQ ID NO: 1) or an amino acid sequence obtained by substituting, deleting, adding or inserting 1-3 amino acids in the amino acid sequence depicted in SEQ ID NO: 1. And X1 is A, MeA, F or MeF. And X2 is V, T, E, Q or W. X3 is A, R, Y or D. And X4 is F, MeF, L or MeF. And X5 is D, E, S, P or V. And X6 is (S)-2-aminoheptanoic acid (Ahp), R, L-n-leucine (Nle), (S)-2, 7-diaminoheptanoic acid (Hty) or S. The formula (I) is shown in the description. And X7 is S, A, L-alpha-aminobutyric acid (Abu), D, Q or V. [课题]本发明提供一种与c-Met蛋白结合的肽复合物。[解决手段]一种包含肽A的肽复合物,其中,肽A是由X1-X2-X3-V-S-X4-D-X5-D-X6-P-R-W-X7-MeC(序列号1)所记载的氨基酸序列所构成的肽,或由序列号1所记载的氨基酸序列中1~3个氨基酸经取代、缺失、加成或插入的氨基酸序列所构成。X1为A、MeA、F或MeF。X2为V、T、E、Q或W。X3为A、R、Y或D。X4为F、MeF、L或MeF。X5为D、E、S、P或V。X6为(S)-2-氨基庚酸(Ahp)、R、L-正亮氨酸(Nle)、(S)-2,7-二氨基庚酸(Hty)或S。X7为S、A、L-α-氨基