Preparation method and application of 2-substituted aryl acetonitrile compound

The invention provides a preparation method and application of a 2-substituted aryl acetonitrile compound. According to the method, substituted benzene and 2-cyano carboxylic ester are used as raw materials and directly react under the action of alkali to obtain the 2-substituted aryl acetonitrile compound, and the reaction formula is as follows: # imgabs0 #. Compared with the prior art, the method provided by the invention has the advantages that the yield is high, a transition metal catalyst and strong alkali are not required to be used, and harsh reaction conditions are avoided. 本发明提供一种2-取代芳基乙腈类化合物的制备方法及其应用。该方法以取代苯和2-氰基羧酸酯为原料，在碱的作用下直接反应得到2-取代芳基乙腈类化合物，反应式如下：#imgabs0#与现有技术相比，本发明提供的方法收率高，无需使用过渡金属催化剂，无需使用强碱，避免了苛刻的反应条件。