Multi-modal contrast agent as well as preparation method and application thereof
The invention provides a multi-modal contrast agent and a preparation method and application thereof.The multi-modal contrast agent is prepared from, by weight, 1 part of a fluorescent precursor, 10-15 parts of a contrast agent, 5-8 parts of dipalmitoyl phosphatidylcholine and 1-3 parts of cholester...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides a multi-modal contrast agent and a preparation method and application thereof.The multi-modal contrast agent is prepared from, by weight, 1 part of a fluorescent precursor, 10-15 parts of a contrast agent, 5-8 parts of dipalmitoyl phosphatidylcholine and 1-3 parts of cholesterol, the fluorescent precursor is of a structure shown in the formula 1, the relaxation rate is increased, and the contrast agent can be used for preparing the contrast agent. And the limitations of low sensitivity and high background noise of MRI are overcome. MRI and fluorescence imaging are combined through complementarity of MRI and fluorescence imaging to achieve bimodal imaging, the multi-modal contrast agent is used for monitoring biological distribution of cells input into a human body, based on the advantages of large tissue penetration depth, high spatial resolution, high signal-to-noise ratio, high sensitivity and the like, a high-resolution imaging result can be obtained, and the imaging effect is good. |
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