Antigen binding proteins targeting streptococcus pneumoniae hemolysin and uses thereof

Provided is an isolated antigen binding protein comprising at least one CDR in an antibody heavy chain variable region VH, the VH comprising an amino acid sequence as shown in SEQ ID NO: 39. The present invention provides isolated antigen binding proteins capable of specifically binding to Streptococcus pneumoniae hemolysin proteins and variants thereof, and uses of the isolated antigen binding proteins in the prevention and/or treatment of diseases and/or conditions infected by Streptococcus pneumoniae. 提供一种分离的抗原结合蛋白，其包含抗体重链可变区VH中的至少一个CDR，所述VH包含SEQ ID NO:39所示的氨基酸序列。所述分离的抗原结合蛋白能够特异性结合肺炎链球菌溶血素蛋白及其变体，还提供了所述分离的抗原结合蛋白在预防和/或治疗肺炎链球菌感染的疾病和/或病症中的用途。