3-(1-oxoisoindoline-2-yl) piperidine-2, 6-dione derivative and medical application thereof

3-(1-oxoisoindoline-2-yl) piperidine-2, 6-dione derivative and medical application thereof

The present application relates to compounds of formula (I) and pharmaceutical compositions comprising these compounds and their use in reducing the expression levels of Wide Interval Zinc Finger Motif (WIZ) or inducing the expression of fetal hemoglobin (HbF) and in the treatment of hereditary hema...

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Bibliographische Detailangaben
Hauptverfasser: BONAZZI SIMONE, DEWHURST JAMES, SONG MINGMIN, KERRIGAN JOHN R, O 'BRIEN GARY, TING, PATRICK, Y, CERNIJENKO ARKADIY, COBB JAMES S, THOMSEN NOEL MARIE-FRANCE
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present application relates to compounds of formula (I) and pharmaceutical compositions comprising these compounds and their use in reducing the expression levels of Wide Interval Zinc Finger Motif (WIZ) or inducing the expression of fetal hemoglobin (HbF) and in the treatment of hereditary hematological disorders (e.g., hemoglobinopathy, e.g., beta-hemoglobinopathy) such as sickle cell disease and beta-thalassemia. # imgabs0 # 本申请涉及式(I)的化合物和包含这些化合物的药物组合物以及它们在降低宽间隔锌指基序(WIZ)表达水平或诱导胎儿血红蛋白(HbF)表达以及在治疗遗传性血液病(例如血红蛋白病，例如β-血红蛋白病)诸如镰状细胞病和β-地中海贫血中的用途。#imgabs0#