Synthesis method of 3-difluoromethylthio-substituted indole compound

The invention discloses a synthesis method of a 3-difluoromethylthio-substituted indole compound, which comprises the following steps: dissolving an o-alkynyl aniline derivative and a difluoromethylthio reagent in an organic solvent, adding a cyclizing reagent, and reacting to obtain the 3-difluoromethylthio-substituted indole compound. The reaction general formula is # imgabs0 #, wherein R1 is a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom or methyl; r2 is a phenyl group, a 4-methoxyphenyl group or a cyclopropyl group; and R3 is p-toluenesulfonyl or methylsulfonyl. The synthesis of the target product is realized by a one-step method, and the method has the advantages of simple operation, cheap and easily available raw materials, mild reaction conditions, short reaction time, ideal yield and the like. 本发明公开了一种3-二氟甲硫基取代的吲哚类化合物的合成方法，将邻炔基苯胺衍生物和二氟甲硫基试剂溶于有机溶剂中，加入环化试剂，反应后得到3-二氟甲硫基取代的吲哚类化合物；反应通式如下：#imgabs0#其中：R1为氢原子、氟原子、氯原子、溴原子或甲基；R2为苯基、4-甲氧基苯基或环丙基；R3为对甲苯磺酰基或甲磺酰基。本发明一步法实现目标产物的合成，具有操作简单，原料价廉易得，反应条件