Application of CFTR correction agent in preparation of medicine for treating hyperplasia of mammary glands

The invention provides application of a CFTR correction agent in preparation of a medicine for treating hyperplasia of mammary glands, and belongs to the field of biological pharmacy. Non-clinical pharmacodynamic tests creatively find that the compound tizancatray shown in the formula I can remarkably reduce the diameter and height of a rat nipple and the uterine index in a mammary gland hyperplasia rat model, relieve mammary gland hyperplasia and improve the content level of E2 and PROG in serum, and has a good treatment effect in the aspect of treating mammary gland hyperplasia. The application potential in preparation of medicines for treating hyperplasia of mammary glands is realized. 本发明提供一种CFTR矫正剂在制备治疗乳腺增生症的药物中的应用，属于生物制药领域。本发明创造性地通过非临床药效学试验发现式Ⅰ所示化合物替扎卡托在乳腺增生大鼠模型中能显著降低大鼠乳头直径、高度和子宫指数，缓解乳腺增生，改善血清中E2和PROG含量水平，在治疗乳腺增生症方面具有很好的治疗效果。具备制备用于治疗乳腺增生症的药物中的应用的潜力。