Antibacterial temperature-sensitive hydrogel for treating chronic otitis media as well as preparation method and application of antibacterial temperature-sensitive hydrogel

The invention relates to the field of medical application of biological hydrogel, and discloses a preparation method of antibacterial temperature-sensitive hydrogel for treating chronic otitis media, which comprises the following steps: adding Pluronic F127 into ultrapure water at low temperature, and stirring until Pluronic F127 is completely dissolved to form a temperature-sensitive hydrogel skeleton; the preparation method comprises the following steps: adding 1%-3% by mass of acetic acid and chitosan or ofloxacin solution into Pluronic F127 solution, and stirring at low temperature to form the temperature-sensitive hydrogel. According to the antibacterial temperature-sensitive hydrogel prepared by the invention, the temperature-sensitive characteristic of Pluronic F127 is utilized, and the Pluronic F127 is used as a temperature-sensitive skeleton to retain an antibacterial drug in a middle ear cavity, so that the drug can be retained in the middle ear cavity for a long time, and a novel otitis media treat