Motion artifact reduction in computed tomography

A method of imaging a region (502) of a patient anatomical structure having a target volume comprises: performing automatic segmentation of a high contrast portion 501 of a first reconstructed volume of the region to generate a three-dimensional (3D) representation of the high contrast portion disposed within the region; and generating a two-dimensional (2D) mask projection set of the region by performing a forward projection process on the 3D representation, where each 2D mask projection in the 2D mask projection set includes position information indicating pixels occluded by the high contrast portion during the forward projection process performed on the 3D representation. Based on the acquired 2D projection set and the position information, the method further includes generating a corrected 2D projection set of the region in which the high contrast portion is removed from each of the corrected projections; and generating a second reconstructed volume of the region based on the corrected 2D projection, wher