Methods and compositions for delivery of retroviral particles

The present disclosure provides methods and compositions for modifying lymphocytes, such as T cells and/or NK cells, for example in vivo. The disclosed compositions may comprise replication-free recombinant retroviral particles (RIPs), formulations thereof, and administration of the RIP formulations...

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Bibliographische Detailangaben
Hauptverfasser:	KUNDU, ANIPAN, FROST GREGORY IAN, RIC, D, WEIGANDT, FR, HENKELMAN, JOHN, R., III
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides methods and compositions for modifying lymphocytes, such as T cells and/or NK cells, for example in vivo. The disclosed compositions may comprise replication-free recombinant retroviral particles (RIPs), formulations thereof, and administration of the RIP formulations to a subject. Further, the composition may comprise a chemokine, which comprises a chemokine delivered with and/or associated with the RIP. 本公开提供了用于例如在体内修饰淋巴细胞，例如T细胞和/或NK细胞的方法和组合物。所公开的组合物可以包含无复制能力的重组逆转录病毒颗粒(RIP)、其调配物以及向受试者施用RIP调配物。此外，所述组合物可以包含趋化因子，所述趋化因子包含与RIP一起递送和/或与RIP缔合的趋化因子。