Humanized anti-C5 antibody and factor H fusion proteins and uses thereof

Humanized anti-C5 antibody and factor H fusion proteins and uses thereof

Inhibition of complement signaling using an anti-C5 antibody or a fusion protein thereof is provided. In particular, methods are provided for treating a complement-mediated disease or a complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody fusion protein...

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Bibliographische Detailangaben
Hauptverfasser: GULLIPALLI, DAMODARA RAO, CUI PING, SONG WENCHAO, ZHU XIHUA, MIWA TAKASHI, XU YINGYING, ZHANG JIANJUN, SATO SAYAKA
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Inhibition of complement signaling using an anti-C5 antibody or a fusion protein thereof is provided. In particular, methods are provided for treating a complement-mediated disease or a complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody fusion protein thereof. 提供了使用抗-C5抗体或其融合蛋白对补体信号转导的抑制。具体地，提供了通过使个体与其抗-C5抗体融合蛋白接触来治疗所述个体中补体-介导的疾病或补体-介导的病症的方法。