Preparation method and application of thiadiazole histone deacetylase inhibitor compound

The invention relates to the field of medicinal chemistry, and provides a novel hydroxamic acid HDACi containing a thiadiazole structure, which comprises pharmaceutically acceptable salts, metabolites, isomers, prodrugs and the like of the hydroxamic acid HDACi. The invention also discloses a preparation method of the compound and application of the compound as a novel HDACi. A hydroxamic acid structural skeleton is introduced on the basis of a thiadiazole structure, a novel hydroxamic acid compound containing the thiadiazole structure is designed and synthesized, the compound combines the advantages of the thiadiazole and hydroxamic acid structures, and the compound can be used as a histone deacetylase inhibitor to be put into drugs for preventing and treating cancers or inflammation; the compound can also be used in anti-tumor treatment drugs after chemotherapy failure caused by induction of acquired drug resistance; the structure of the novel imgabs0 # is shown as follows: # imgabs0 # 本发明涉及药物化学领域，提供了一类新型的含