Lyophilized rabies vaccine composition as well as preparation method and application thereof

The invention provides a rabies vaccine composition for freeze-drying. The composition comprises an inactivated rabies virus stock solution, carbohydrates and a high polymer material freeze-drying protective agent. The composition can form a loose cake-like lyophilisate that can be reconstituted for administration as intramuscular injection. The prepared freeze-dried rabies vaccine human diploid cell composition for human use is simple in formula, good in preparation appearance, good in antigen content and titer stability and suitable for large-scale industrial production. 本公开提供了一种冻干用狂犬病疫苗组合物，该组合物包括灭活的狂犬病毒原液、糖类物质和高分子材料冻干保护剂。该组合物可形成疏松蛋糕状冻干物，可被重构作为肌肉注射施用。本公开制备的冻干人用狂犬病疫苗人二倍体细胞组合物组方简单、制剂外观良好、抗原含量与效价稳定性好、适合于大规模工业化生产。