Application of swim bladder glycosaminoglycan in preparation of intestinal injury medicine

The invention belongs to the technical field of biological medicines, and relates to application of swimming bladder glycosaminoglycan in preparation of intestinal injury medicines. The swim bladder glycosaminoglycan provided by the invention has an obvious intervention effect on mouse intestinal in...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG JIELIANG, OU JIEYING, LIU XIAOFEI, LIU SHOUCHUN, GUO XIAOLIN, LI RUI, ZHONG SAIYI, ZHONG AITONG, HUANG HOUPEI, WANG ZHUO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of biological medicines, and relates to application of swimming bladder glycosaminoglycan in preparation of intestinal injury medicines. The swim bladder glycosaminoglycan provided by the invention has an obvious intervention effect on mouse intestinal injury, and can improve pathological injuries such as colon length shortening, colon crypt disorder, inflammation infiltration and the like. Test data show that the swim bladder glycosaminoglycan can reduce the content of inflammatory factors IL-2 and endotoxin of the body, relieve the inflammation level of the body and increase the permeability of the intestinal tract, can significantly increase the SOD activity and GSH content in colon tissue, significantly reduce the MPO activity and MDA content, and slow down the occurrence of oxidative stress and inflammation of the intestinal tract. The swim bladder glycosaminoglycan disclosed by the invention has a good application prospect in preparation of intestinal injury