Animal model construction method for simulating CO poisoning

The invention discloses an animal model construction method for simulating CO poisoning. The method comprises the following steps: selecting a preset number of target laboratory mice; the target laboratory mouse is a rat or a mouse; determining the target injection dosage of CO according to the weig...

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Hauptverfasser: YANG KUNLI, YAN YAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an animal model construction method for simulating CO poisoning. The method comprises the following steps: selecting a preset number of target laboratory mice; the target laboratory mouse is a rat or a mouse; determining the target injection dosage of CO according to the weight of the target laboratory mouse; fixing the target experimental mouse, inserting a syringe needle into the abdominal cavity of the target experimental mouse, and performing CO intraperitoneal injection according to the target injection dosage to obtain an animal model; wherein the syringe needle is connected with the CO storage tank through a pipeline, and a flow detector is arranged on the pipeline. Therefore, by adopting the intraperitoneal injection method with the controllable CO flow, the animal model of CO poisoning can be manufactured more efficiently and safely, and a new modeling mode is provided for research on pathological reaction caused by CO poisoning and the like. Moreover, during model constructio