Crystalline forms of (4S)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32, 5-dioxo-14-(trifluoromethyl)-32H-6-aza-3 (4, 1)-pyridin-1 (1)-[1, 2, 3] triazole-2 (1, 2), 7 (1)-5-diphenylheptane-74-carboxamide

The present invention relates to crystalline forms of (4S)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32, 5-dioxo-14-(trifluoromethyl)-32H-6-aza-3 (4, 1)-pyridin-1 (1)-[1, 2, 3] triazole-2 (1, 2), 7 (1)-5-diphenylheptane-74-carboxamide, i.e. Crystal variant I and crystal variant II, processes for their...

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Hauptverfasser: CHIM KWOK, SOWA MARK, RU HRIG, SUSANNE, RUBINO FABIO, LEVELLAIN, GUILLAUME, OLENIK BRITTA, JAKOB TOBIAS
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to crystalline forms of (4S)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32, 5-dioxo-14-(trifluoromethyl)-32H-6-aza-3 (4, 1)-pyridin-1 (1)-[1, 2, 3] triazole-2 (1, 2), 7 (1)-5-diphenylheptane-74-carboxamide, i.e. Crystal variant I and crystal variant II, processes for their preparation, pharmaceutical compositions comprising them and their use in the control of diseases. 本发明涉及(4S)-24-氯-4-乙基-73-氟-35-甲氧基-32,5-二氧代-14-(三氟甲基)-32H-6-氮杂-3(4,1)-吡啶-1(1)-[1,2,3]三唑-2(1,2),7(1)-5二苯庚烷-74-甲酰胺的结晶形式(即晶体变型I和晶体变型II)、其制备方法、包含其的药物组合物及其在防治疾病中的用途。