Oral hybrid membrane vesicle as well as preparation method and antibacterial application thereof

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an oral hybrid membrane vesicle as well as a preparation method and antibacterial application thereof. The invention provides a hybrid membrane vesicle. The hybrid membrane vesicle is formed by hybridizing turmeric derived exosome (EVs) and helicobacter pylori bacterial membrane vesicles (DMVs), and the hybrid membrane vesicle plays a strong antibacterial role under the ultrasonic action. The hybrid membrane bionic vesicle composed of the turmeric derived exosome and the helicobacter pylori double-layer membrane vesicle combines the advantages of the two membranes, realizes targeted retention at an infected part, and realizes a sonodynamic efficient sterilization function through ultrasonic response. Due to the characteristics of simple preparation, high yield, good biological safety and the like, a promising treatment method is provided for helicobacter pylori infection, and the helicobacter pylori vaccine has the