Sustained-release microsphere preparation containing betamethasone medicine and preparation method of sustained-release microsphere preparation

The invention discloses a sustained-release microsphere preparation containing a betamethasone drug, which is characterized in that a polylactic acid-glycolic acid copolymer is used as a base material, the betamethasone drug is used as an effective drug component, and sustained-release microspheres...

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Bibliographische Detailangaben
Hauptverfasser: REN YANJI, LI MING, CHEN ZHIHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a sustained-release microsphere preparation containing a betamethasone drug, which is characterized in that a polylactic acid-glycolic acid copolymer is used as a base material, the betamethasone drug is used as an effective drug component, and sustained-release microspheres of the betamethasone drug with a porous structure and uniform particle size are obtained through a microfluidic technology. According to the betamethasone-polylactic acid-glycolic acid copolymer microspheres prepared by the invention, the surfaces of the microspheres have wrinkles, the microspheres are easy to adhere to cell surfaces, the prepared microspheres are internally provided with pore channels, and compared with materials, the microspheres are beneficial to drug sustained release, the action time of drugs can be prolonged, frequent injection and medication are avoided, the compliance of the drugs is reduced, and the side effects of the drugs are reduced; the polylactic acid-glycolic acid copolymer is adopt