Lentiviruses for producing cells expressing anti-CD19 chimeric antigen receptors

Compositions and methods are provided for transducing immune cells in vivo, wherein a viral particle comprising a polynucleotide encoding a chimeric antigen receptor and a multi-zoned cell surface receptor is administered to a subject. 提供了用于在体内转导免疫细胞的组合物和方法，其中向受试者施用包括编码嵌合抗原受体和多分区细胞表面受体的多核苷酸的病毒颗粒。