Anti-transferrin receptor fusion proteins and methods of use thereof

Anti-transferrin receptor fusion proteins and methods of use thereof

Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and anti-transferrin receptor (TfR) antibodies as described herein, and methods of their use. 某些实施方案提供了包含艾杜糖醛酸2-...

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Bibliographische Detailangaben
Hauptverfasser: WANG JUNHUA, ARGUELLO, ANTHONY, GEESE THOMAS, MAHON CHRISTOPHER S, KANNAN GOPINATHAN, CARIOLIS MICHAEL S
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and anti-transferrin receptor (TfR) antibodies as described herein, and methods of their use. 某些实施方案提供了包含艾杜糖醛酸2-硫酸酯酶(IDS)氨基酸序列、IDS变体氨基酸序列或其催化活性片段的融合蛋白；和如本文所述的抗转铁蛋白受体(TfR)抗体，以及它们的使用方法。