Methods and uses of antibody drug conjugates for treatment of cancer

The invention belongs to the technical field of biological medicines, and relates to a method for treating cancers by using an antibody drug conjugate. Specifically, the invention relates to application of the antibody drug conjugate as shown in the formula (I), pharmaceutically acceptable salt, stereoisomer or metabolite of the antibody drug conjugate or solvates of the antibody drug conjugate and the pharmaceutically acceptable salt, the stereoisomer or the metabolite in preparation of drugs for preventing and/or treating cancers with HER2 expression, amplification or mutation, wherein A is a group obtained by removing n amino groups from an anti-HER2 antibody or an active fragment or variant thereof, preferably, A is a group obtained by removing n amino groups from trastuzumab or pertuzumab; n is selected from 1-10, for example, 2-10 or 2-8; preferably, n is an integer of 1, 2, 3, 4, 5, 6, 7 or 8. #imgabs0#本发明属于生物医药技术领域，涉及抗体药物偶联物治疗癌症的方法。具体而言，本发明涉及式(I)的抗体药物偶联物、其药学上可接受的盐、立体异构体或代谢物或者前述各项的溶剂化物在制备用于预防和/或治疗HER2表