Macrocyclic compounds with heterocyclic P2 'groups as factor XIA inhibitors

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. The invention als...

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Hauptverfasser:	DE LUCCA INDAWATI, PABBISETTY KUMAR B, WEXLER RUTH R, FANG TIANAN, WANG YUFENG, ZHU YEHENG, ORWAT MICHAEL J, DILGER ANDREW K, PINTO DONALD J P, EWING WILLIAM R, CORTE JAMES R, YANG WU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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