Macrocyclic compounds with heterocyclic P2 'groups as factor XIA inhibitors

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. The invention als...

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Bibliographische Detailangaben
Hauptverfasser:	DE LUCCA INDAWATI, PABBISETTY KUMAR B, WEXLER RUTH R, FANG TIANAN, WANG YUFENG, ZHU YEHENG, ORWAT MICHAEL J, DILGER ANDREW K, PINTO DONALD J P, EWING WILLIAM R, CORTE JAMES R, YANG WU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. The invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory conditions using the same. # imgabs0 # 本发明提供式(I)化合物或其立体异构体、互变异构体或药用盐，其中所有变量均如本文中所定义。这些化合物为选择性因子XIa抑制剂或FXIa及血浆激肽释放酶的双重抑制剂。本发明还涉及包含这些化合物的药物组合物及使用其治疗血栓栓塞性和/或炎性病症的方法。#imgabs0#