Secretable payload modulation

Described herein are chimeric proteins comprising a membrane cleavable chimeric protein and a degrader-fusion chimeric protein. Also described herein are nucleic acids, pharmaceutical compositions, methods, and methods of treatment involving the chimeric proteins. 本文描述了嵌合蛋白，其包含膜可切割嵌合蛋白和降解子-融合嵌合蛋白。本文还描述了涉及所述嵌合蛋白的核酸、药物组合物、方法以及治疗方法。