Method for measuring in-vitro phosphorus binding force of lanthanum carbonate chewable tablets

The invention provides a method for determining the in-vitro phosphorus binding force of lanthanum carbonate chewable tablets, and belongs to the technical field of analysis and testing by separating substances into various components through mass spectrometry. Preparing a phosphate stock solution,...

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Hauptverfasser: LI JIALIN, XU CHENGMIAO, LUO JINWEN, ZHOU YANG, YU YANG, HE LI, LI CHUNHUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a method for determining the in-vitro phosphorus binding force of lanthanum carbonate chewable tablets, and belongs to the technical field of analysis and testing by separating substances into various components through mass spectrometry. Preparing a phosphate stock solution, a pH medium, a working linear solution and a test solution, detecting the working linear standard solution and the test solution by adopting ICP-MS (Inductively Coupled Plasma Mass Spectrometry), and calculating the phosphorus binding force. The method is used for testing the in-vitro phosphorus binding force, and has the advantages of being simple, convenient, stable, high in accuracy, capable of greatly improving the sensitivity and the like. 本申请提供一种碳酸镧咀嚼片体外磷结合力的测定方法,属于质谱法将物质分离成各个组分达到分析测试技术领域。配制磷酸盐储备液、pH介质、工作线性溶液、供试品溶液,采用ICP-MS对工作线性标准溶液和供试品溶液进行检测,计算磷结合力。将本申请用于体外磷结合力的测试,具有简单方便、稳定、准确度较高、且能大大提高灵敏度等优点。