Tumor neoantigen polypeptide aiming at R249S mutation of TP53 gene and application of tumor neoantigen polypeptide
The invention belongs to the technical field of tumor immunotherapy, and particularly relates to a tumor neoantigen polypeptide aiming at R249S mutation of a TP53 gene and application of the tumor neoantigen polypeptide. The technical problem to be solved by the invention is to provide a specific im...
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| creator | WEI YUQUAN YANG LI LI QIU MAO WEI HAO QING DING ZHENYU SHU YANG WU QIUJI XU HENG |
| description | The invention belongs to the technical field of tumor immunotherapy, and particularly relates to a tumor neoantigen polypeptide aiming at R249S mutation of a TP53 gene and application of the tumor neoantigen polypeptide. The technical problem to be solved by the invention is to provide a specific immunotherapy scheme for R249S mutation of a tumor driver gene TP53 based on MHC-II molecules. In order to solve the technical problem, the invention adopts the technical scheme that the tumor neoantigen polypeptide related to R249S mutation of the tumor driver gene TP53 is provided. The antigen polypeptide disclosed by the invention can be used for remarkably activating human body specific T cells aiming at TP53-R249S mutation so as to improve the killing ability of the T cells on TP53-R249S mutation tumor cells, and can be used for preparing medicines for preventing and treating TP53-R249S mutation tumors, especially for preparing tumor cell vaccines.
本发明属于肿瘤免疫治疗技术领域，具体涉及针对TP53基因R249S突变的肿瘤新抗原多肽及其应用。本发明要解决的技术问题是提供一种 |
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本发明属于肿瘤免疫治疗技术领域，具体涉及针对TP53基因R249S突变的肿瘤新抗原多肽及其应用。本发明要解决的技术问题是提供一种</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231031&DB=EPODOC&CC=CN&NR=116970058A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231031&DB=EPODOC&CC=CN&NR=116970058A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WEI YUQUAN</creatorcontrib><creatorcontrib>YANG LI</creatorcontrib><creatorcontrib>LI QIU</creatorcontrib><creatorcontrib>MAO WEI</creatorcontrib><creatorcontrib>HAO QING</creatorcontrib><creatorcontrib>DING ZHENYU</creatorcontrib><creatorcontrib>SHU YANG</creatorcontrib><creatorcontrib>WU QIUJI</creatorcontrib><creatorcontrib>XU HENG</creatorcontrib><title>Tumor neoantigen polypeptide aiming at R249S mutation of TP53 gene and application of tumor neoantigen polypeptide</title><description>The invention belongs to the technical field of tumor immunotherapy, and particularly relates to a tumor neoantigen polypeptide aiming at R249S mutation of a TP53 gene and application of the tumor neoantigen polypeptide. The technical problem to be solved by the invention is to provide a specific immunotherapy scheme for R249S mutation of a tumor driver gene TP53 based on MHC-II molecules. In order to solve the technical problem, the invention adopts the technical scheme that the tumor neoantigen polypeptide related to R249S mutation of the tumor driver gene TP53 is provided. The antigen polypeptide disclosed by the invention can be used for remarkably activating human body specific T cells aiming at TP53-R249S mutation so as to improve the killing ability of the T cells on TP53-R249S mutation tumor cells, and can be used for preparing medicines for preventing and treating TP53-R249S mutation tumors, especially for preparing tumor cell vaccines.
本发明属于肿瘤免疫治疗技术领域，具体涉及针对TP53基因R249S突变的肿瘤新抗原多肽及其应用。本发明要解决的技术问题是提供一种</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZCgKKc3NL1LIS81PzCvJTE_NUyjIz6ksSC0oyUxJVUjMzM3MS1dILFEIMjKxDFbILS1JLMnMz1PIT1MICTA1VgBqAKrKS1FILCjIyUyGS5bgMZWHgTUtMac4lRdKczMourmGOHvophbkx6cWFyQmAw0tiXf2MzQ0szQ3MDC1cDQmRg0AbcxDWg</recordid><startdate>20231031</startdate><enddate>20231031</enddate><creator>WEI YUQUAN</creator><creator>YANG LI</creator><creator>LI QIU</creator><creator>MAO WEI</creator><creator>HAO QING</creator><creator>DING ZHENYU</creator><creator>SHU YANG</creator><creator>WU QIUJI</creator><creator>XU HENG</creator><scope>EVB</scope></search><sort><creationdate>20231031</creationdate><title>Tumor neoantigen polypeptide aiming at R249S mutation of TP53 gene and application of tumor neoantigen polypeptide</title><author>WEI YUQUAN ; YANG LI ; LI QIU ; MAO WEI ; HAO QING ; DING ZHENYU ; SHU YANG ; WU QIUJI ; XU HENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116970058A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WEI YUQUAN</creatorcontrib><creatorcontrib>YANG LI</creatorcontrib><creatorcontrib>LI QIU</creatorcontrib><creatorcontrib>MAO WEI</creatorcontrib><creatorcontrib>HAO QING</creatorcontrib><creatorcontrib>DING ZHENYU</creatorcontrib><creatorcontrib>SHU YANG</creatorcontrib><creatorcontrib>WU QIUJI</creatorcontrib><creatorcontrib>XU HENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WEI YUQUAN</au><au>YANG LI</au><au>LI QIU</au><au>MAO WEI</au><au>HAO QING</au><au>DING ZHENYU</au><au>SHU YANG</au><au>WU QIUJI</au><au>XU HENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Tumor neoantigen polypeptide aiming at R249S mutation of TP53 gene and application of tumor neoantigen polypeptide</title><date>2023-10-31</date><risdate>2023</risdate><abstract>The invention belongs to the technical field of tumor immunotherapy, and particularly relates to a tumor neoantigen polypeptide aiming at R249S mutation of a TP53 gene and application of the tumor neoantigen polypeptide. The technical problem to be solved by the invention is to provide a specific immunotherapy scheme for R249S mutation of a tumor driver gene TP53 based on MHC-II molecules. In order to solve the technical problem, the invention adopts the technical scheme that the tumor neoantigen polypeptide related to R249S mutation of the tumor driver gene TP53 is provided. The antigen polypeptide disclosed by the invention can be used for remarkably activating human body specific T cells aiming at TP53-R249S mutation so as to improve the killing ability of the T cells on TP53-R249S mutation tumor cells, and can be used for preparing medicines for preventing and treating TP53-R249S mutation tumors, especially for preparing tumor cell vaccines.
本发明属于肿瘤免疫治疗技术领域，具体涉及针对TP53基因R249S突变的肿瘤新抗原多肽及其应用。本发明要解决的技术问题是提供一种</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Tumor neoantigen polypeptide aiming at R249S mutation of TP53 gene and application of tumor neoantigen polypeptide |
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