Tumor neoantigen polypeptide aiming at R249S mutation of TP53 gene and application of tumor neoantigen polypeptide

The invention belongs to the technical field of tumor immunotherapy, and particularly relates to a tumor neoantigen polypeptide aiming at R249S mutation of a TP53 gene and application of the tumor neoantigen polypeptide. The technical problem to be solved by the invention is to provide a specific immunotherapy scheme for R249S mutation of a tumor driver gene TP53 based on MHC-II molecules. In order to solve the technical problem, the invention adopts the technical scheme that the tumor neoantigen polypeptide related to R249S mutation of the tumor driver gene TP53 is provided. The antigen polypeptide disclosed by the invention can be used for remarkably activating human body specific T cells aiming at TP53-R249S mutation so as to improve the killing ability of the T cells on TP53-R249S mutation tumor cells, and can be used for preparing medicines for preventing and treating TP53-R249S mutation tumors, especially for preparing tumor cell vaccines. 本发明属于肿瘤免疫治疗技术领域，具体涉及针对TP53基因R249S突变的肿瘤新抗原多肽及其应用。本发明要解决的技术问题是提供一种