Fluorinated monosaccharide derivative as well as synthesis method and application thereof
The invention discloses a fluorinated monosaccharide derivative and a synthesis method and application thereof, the fluorinated monosaccharide derivative is composed of three parts, the first part is a 1-substituted monosaccharide group, the second part is a fluorine signal source perfluoro-tert-but...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a fluorinated monosaccharide derivative and a synthesis method and application thereof, the fluorinated monosaccharide derivative is composed of three parts, the first part is a 1-substituted monosaccharide group, the second part is a fluorine signal source perfluoro-tert-butyl ether group, and the third part is a triazole ring connecting the two parts. The fluorinated monosaccharide derivative disclosed by the invention retains 2-site hydroxyl and 6-site hydroxyl of monosaccharide, so that identification of the monosaccharide in vivo is not influenced, and the fluorinated monosaccharide derivative has good water solubility and biocompatibility. The derivative contains 9 magnetically equivalent fluorine-19, can generate a single and strong fluorine signal, and avoids the problems of fluorine signal splitting or low fluorine atom utilization rate and the like. The fluorine signal intensity and the compound concentration are in a good linear relation, a basis is provided for in-vivo quan |
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