Preparation method and intermediate of deuterated o-aminophenol

The invention discloses a preparation method and an intermediate of deuterated o-aminophenol. Specifically, the invention discloses a preparation method of deuterated o-aminophenol, which comprises the following steps: under the action of an acid, a compound V is subjected to a deprotection reaction as shown in the specification to prepare a compound IV, the molar ratio of the acid to the compound V is (1.4-1.6): 1, and PG is an amino protecting group removed under an acidic condition. The preparation method of the deuterated o-aminophenol has one or more of the following advantages: (1) the deuteration rate of the product deuterated o-aminophenol is high; (2) the yield is high; (3) the operation is simple and convenient. # imgabs0 # 本发明公开了氘代邻氨基苯酚的制备方法及其中间体。具体地，本发明公开了一种氘代邻氨基苯酚的制备方法，其包含以下步骤：在酸的作用下，化合物V进行如下所示的脱保护反应，制备得到化合物IV，即可，其中，所述的酸与所述的化合物V的摩尔比为(1.4～1.6)：1，其中，PG为在酸性条件下脱除的氨基保护基。本发明的氘代邻氨基苯酚制备方法具有以下优点的一种或多种：(1)产物氘代邻氨基苯酚的氘代率高；(2)产率高；(3)操作简便。#imgabs0#