Improved polyethyleneimine polyethylene glycol carriers

Provided are multimers of a double-stranded RNA and a polymeric conjugate wherein the polymeric conjugate consists of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties, each PEG moiety being conjugated via a linker to a targeting moiety capable of binding...

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Bibliographische Detailangaben
Hauptverfasser:	JOUBRAN, SALIM, LEVITZKI, ALEX, ZIEGLER MAYA, TALHAMI ALAA, LANGOUET, YAIR, SHIR, ALEXEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are multimers of a double-stranded RNA and a polymeric conjugate wherein the polymeric conjugate consists of a linear polyethyleneimine covalently linked to one or more polyethylene glycol (PEG) moieties, each PEG moiety being conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. 提供双链RNA和聚合缀合物的多聚物，其中所述聚合缀合物由与一个或多个聚乙二醇(PEG)部分共价连接的线型聚乙烯亚胺组成，各PEG部分经接头与能够结合癌症抗原的靶向部分缀合。