NOVEL ANTIBODIES TO CD55 AND USES THEREOF

The invention relates to an antibody specifically bound with CD55 or an antigen binding fragment thereof. And a composition for preventing, treating and/or diagnosing cancer comprising the same. The antibody according to the present invention exhibits high binding force and inhibitory ability to CD55 protein that promotes tumor proliferation by inhibiting complement immune mechanism, and thus can be used as an effective therapeutic composition for various CD55-mediated diseases. Furthermore, the antibody according to the present invention can be usefully used as an effective therapeutic adjuvant which fundamentally eliminates drug resistance in various diseases in which drug resistance is caused to a therapeutic agent having complement-dependent cytotoxicity (CDC) as the mechanism of action, and which significantly improves therapeutic responsiveness. 本发明涉及一种与CD55特异性结合的抗体或其抗原结合片段；以及包含其的用于预防、治疗和/或诊断癌症的组合物。本发明的抗体对通过抑制补体免疫机制来促进肿瘤增殖的CD55蛋白表现出高结合力以及抑制力，从而可以用作各种由CD55介导的疾病的有效的治疗组合物。并且，本发明的抗体可以有用地用作有效的治疗佐剂，其从根本上消除由于C