Micromolecular antibacterial polypeptide, preparation method and application thereof

The invention relates to the technical field of antibacterial drugs, in particular to micromolecular antibacterial polypeptide, a preparation method and application thereof. Compared with most of other derivative polypeptides and antibacterial polypeptides disclosed in existing reports, the antibact...

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Bibliographische Detailangaben
Hauptverfasser: ZHAN WENHU, WANG WEI, XIAO BIN, YANG KESHU, CHEN JUNJIE, LUO JUN, GU LING, LIN QUANHAO, ZHOU FANGXING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of antibacterial drugs, in particular to micromolecular antibacterial polypeptide, a preparation method and application thereof. Compared with most of other derivative polypeptides and antibacterial polypeptides disclosed in existing reports, the antibacterial peptide provided by the invention has stronger antibacterial activity. Sterilization activity evaluation is carried out by using various known strains with drug resistance, and results show that the antibacterial peptide provided by the invention has broad-spectrum antibacterial activity on the drug-resistant strains, more comprehensive antibacterial effects and wider indications. 本发明涉及抗菌药物技术领域,特别涉及小分子抗菌多肽、制备方法及其用途。本发明提供的抗菌肽相较于其他大多数衍生多肽以及现有报道中公开的抗菌多肽具有更强的抑菌活性。使用已知具有耐药性的多种菌株开展杀菌活性评价,结果显示,本发明提供的抗菌肽对耐药菌株具有广谱抑菌活性,抑菌效果更全面,适应症更广泛。