Application of BRD7 as target spot in preparation of medicine for treating obesity-related mental diseases

The invention discloses application of a bromine-containing region structural protein BRD7 serving as a target spot in preparation of a medicine for treating obesity-related mental diseases. The medicine is a BRD7 small-molecule inhibitor, and the BRD7 small-molecule inhibitor BI-7273. Experiments p...

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Hauptverfasser: HU ZHAOLAN, ZOU GUANGJING, LUO YANWEI, GAO MENG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of a bromine-containing region structural protein BRD7 serving as a target spot in preparation of a medicine for treating obesity-related mental diseases. The medicine is a BRD7 small-molecule inhibitor, and the BRD7 small-molecule inhibitor BI-7273. Experiments prove that the BRD7 small-molecule inhibitor has a very good treatment effect on related mental diseases caused by obesity as the BRD7 is knocked out by gRNA. The invention proves that obesity-induced anxiety and depression-like behaviors can be obviously improved by inhibiting T cell BRD7 gene expression or inhibiting BRD7 protein activity. The invention discloses a new role of the BRD7 gene in immune cells and obesity-related mental diseases, and designs and prepares medicines or other treatment means for treating obesity-related mental diseases by taking the BRD7 gene or protein as a target spot. 本发明公开了一种以含溴区结构蛋白BRD7为靶点在制备肥胖相关精神疾病药物中的应用,所述药物为BRD7小分子抑制剂,所述BRD7小分子抑制剂BI-7273。本申请通过实验验证了BRD7小分子抑制剂与采用gRNA敲除BRD7一样都对肥胖导致