Immunosuppressant, identification method and application

The invention belongs to the technical field of biological medicines, and discloses an immunosuppressant, an identification method and application, through the difference between the efficiency of sinomenine and naringenin for inducing immature dendritic cells in mouse bone marrow stem cells and the...

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Hauptverfasser: FENG QING, HUANG XIAOYAN, FENG YANGMENG, ZHAO XIANGRONG, XU CUIXIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of biological medicines, and discloses an immunosuppressant, an identification method and application, through the difference between the efficiency of sinomenine and naringenin for inducing immature dendritic cells in mouse bone marrow stem cells and the immunosuppressive effect of induced imDC in a mouse skin transplantation model, in the process of inducing imDC by using the mouse bone marrow stem cells, the immunosuppressive effect of imDC in the mouse bone marrow stem cells is improved, and the immunosuppressive effect of imDC in the mouse bone marrow stem cells is improved. Under the same concentration, the imDC induction purity of the naringenin group is higher than that of the sinomenine group; in a mouse skin transplantation model, the survival time of the naringenin group graft is longer than that of sinomenine. Experimental results show that under the same concentration, the proportion of imDC induced by Nar is higher than that of imDC induced by an SN g