Preparation method of 2-amino-6-(1-methylpiperidine-4-yl carbonyl) pyridine

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of 2-amino-6-(1-methylpiperidine-4-yl carbonyl) pyridine. According to the method, 2-amino-6-(1-methylpiperidine-4-yl carbonyl) pyridine is prepared from 2-bromo-6-(1-methylpiperidine-4-yl carbonyl) pyridine as an initial raw material under the action of L-proline and a catalyst, generation of impurities can be effectively reduced, operation is simple, reaction conditions are mild, the yield of the prepared compound I is high, and the method is suitable for industrial production. High purity can be achieved without further purification, and the method is suitable for industrial production. 本发明属于药物合成技术领域，具体涉及一种2-氨基-6-(1-甲基哌啶-4-基羰基)吡啶的制备方法；本方法以2-溴-6-(1-甲基哌啶-4-基羰基)-吡啶为起始原料，在L-脯氨酸和催化剂作用下制得2-氨基-6-(1-甲基哌啶-4-基羰基)吡啶，可以有效降低杂质生成，且操作简单，反应条件温和，制得的化合物I收率高，无需进一步纯化即具有较高的纯度，适合工业化生产。