Subject-object compound based on antibacterial polypeptide as well as preparation method and application of subject-object compound

The invention discloses a host-guest compound based on antibacterial polypeptide as well as a preparation method and application of the host-guest compound. The host-guest compound based on the antibacterial polypeptide comprises an antibacterial polypeptide formula (I) and a host molecule, the host molecule is at least one of crown ether, a crown ether derivative, calixarene, a calixarene derivative, pillararene, a pillararene derivative, cyclodextrin, a cyclodextrin derivative, cucurbituril and a cucurbituril derivative. The host-guest compound based on the antibacterial polypeptide can destroy the secondary structure of the antibacterial polypeptide, effectively reduces the biotoxicity of the antibacterial polypeptide, and is selectively activated on the surface of bacterial cells, so that high-selectivity killing is performed on bacteria. According to the strategy, the antibacterial peptide with high antibacterial activity and high toxicity can be rapidly optimized, even waste utilization is achieved, and