Screening and identifying method of heart-derived exosome biomarker and application of screening and identifying method

The invention belongs to the field of biological medicine, and relates to a screening and identifying method and application of a heart-derived exosome biomarker. According to the method, exosomes are taken as a main marker, serine peptidase is taken as an auxiliary marker, and the exosomes with spe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	WANG YING, LIAN JIANGFANG, SONG YONGFEI, KIM HYO-JUN, HUANG XIAOYAN, HU JIALE, BA YANNA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention belongs to the field of biological medicine, and relates to a screening and identifying method and application of a heart-derived exosome biomarker. According to the method, exosomes are taken as a main marker, serine peptidase is taken as an auxiliary marker, and the exosomes with specific sources of myocardial cells in blood plasma are sorted based on membrane protein molecules (CORIN) which are specifically and highly expressed in the myocardial cells by the serine peptidase; therefore, exosomes with specific sources of myocardial cells in circulating blood are screened out to explore the occurrence of exosome-mediated primary hypertensive left ventricular hypertrophy. The separated specific exosome is rich in pathological information of a patient with primary hypertensive left ventricular hypertrophy in a myocardial cell stress state, and the separated specific exosome does not have signal interference on disease diagnosis caused by doping of exosomes released by other tissues. 本发明属于生物医药领域，涉