Plasma exosome marker of OSA, screening method and application of plasma exosome marker

The invention discloses a plasma exosome marker of OSA, the marker is ENST00000592016, and a screening method of the plasma exosome marker of OSA comprises a step of high-throughput sequencing and marker screening and a step of biomarker clinical evaluation. The screened plasma exosome marker of the OSA has the advantages of being stable, high in reliability and high in correlation degree, and ENST00000592016 has good diagnosis efficiency when an OSA sample is recognized and is remarkably expressed in the OSA; the diagnostic value of the ENST00000592016 on the OSA is superior to that of the combined diagnosis of the CPR and the HbA1c. 本发明公开了OSA的血浆外泌体标志物，所示标志物为ENST00000592016，OSA的血浆外泌体标志物的筛选方法包括高通量测序及标志物筛选的步骤和生物标记物临床评估的步骤。本发明筛选出的OSA的血浆外泌体标志物具有稳定、可靠性高、关联程度高的优点点，ENST00000592016在识别OSA样本时具有较好的诊断效能，其在OSA中表达显著；ENST00000592016对OSA的诊断价值优于CPR与HbA1c的联合诊断。