Preparation method and application of benzamide and spiro-amide compound

The invention relates to the technical field of organic synthesis, in particular to a preparation method and application of benzamide and spiro-amide compounds. According to the preparation method of the benzamide and spiro-amide compound, the reaction formula is as follows: # imgabs0 #, R1 is pheny...

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Hauptverfasser: CAO CUILIAN, SUN LEI, CHEN WENWEN, TAKEBAYASHI TSUYOSHI, DENG CHANGZHEN, XIE LEI, LIU XIUZHENG, LIU WANXING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of organic synthesis, in particular to a preparation method and application of benzamide and spiro-amide compounds. According to the preparation method of the benzamide and spiro-amide compound, the reaction formula is as follows: # imgabs0 #, R1 is phenyl, polysubstituted or monosubstituted phenyl and benzyl, and R2 is methyl, hydrogen atom, methoxyl, ethyoxyl, benzyloxy and hydroxyl. The compound is synthesized under the conditions of room temperature, visible light catalysis and no need of a photocatalyst, and the method has the advantages of greenness, high efficiency and energy conservation. By changing the reaction substrate, the method can synthesize the spirocyclic amide compound with excellent yield. For common plant fungi, part of products also show good bacteriostatic activity. 本发明涉及有机合成技术领域,具体涉及一种苯并酰胺和螺环酰胺化合物的制备方法和应用。本发明的一种苯并酰胺和螺环酰胺化合物的制备方法,反应式如下:#imgabs0#其中,R1为苯基、多取代或单取代苯基、苄基,R2为甲基、氢原子、甲氧基、乙氧基、苄氧基、羟基。本发明采用室温条件,下可见光催化且不需要光催化剂的条件下,进行了此类化合物的合成,该方法具有绿色、高效和