Low-heat-release antibacterial and anti-inflammatory injectable bone cement as well as preparation method and application thereof

The invention discloses low-heat-release antibacterial and anti-inflammatory injectable bone cement as well as a preparation method and application thereof. The preparation method comprises the following steps: performing double-bond modification on hydroxyapatite powder; the preparation method comp...

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Hauptverfasser: LI QINGJIE, YIN JUN, ZHAO HUAPENG, YAN JINHAO, JIANG WENLONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses low-heat-release antibacterial and anti-inflammatory injectable bone cement as well as a preparation method and application thereof. The preparation method comprises the following steps: performing double-bond modification on hydroxyapatite powder; the preparation method comprises the following steps: grafting double-bond modified hydroxyapatite and sulphobetaine in a free radical polymerization manner to obtain betaine modified hydroxyapatite; the preparation method comprises the following steps: taking a polymethyl methacrylate prepolymer as a liquid phase, taking betaine modified hydroxyapatite and dibenzoyl peroxide which are mixed according to a certain proportion as a solid phase, adding a proper amount of N, N-dimethylaniline, fully stirring until the materials are uniformly mixed, and heating and curing to obtain the low-heat-release antibacterial anti-inflammatory injectable bone cement. The low-heat-release antibacterial and anti-inflammatory injectable bone cement prepared b