Application of shepaperil isonicotinate in preparation of medicine for preventing and/or treating pulmonary arterial hypertension

The invention relates to the technical field of new pharmacologic action of Xipaperil, and particularly discloses application of Xipaperil to preparation of a medicine for preventing and/or treating pulmonary arterial hypertension. Pulmonary arterial hypertension is caused by abnormal proliferation of pulmonary artery smooth muscles, right heart failure can be caused, and the disability rate and the case fatality rate are high. The application has the beneficial effects that the Xipaperamide can prevent the pulmonary arterial hypertension and/or prevent the pulmonary arterial hypertension disease from deepening by inhibiting progressive increase of the pulmonary arterial pressure, or inhibiting right ventricular hypertrophy or inhibiting pulmonary vascular remodeling; the compound also can inhibit the activation of RhoA kinase by improving the expression of p27kip1 which is one of the main downstream factors of RhoA kinase, thereby inhibiting pulmonary artery smooth muscle hyperplasia, inhibiting pulmonary ar