Application of nitrothiazole derivative in preparation of bacteriostatic agent for inhibiting helicobacter pylori

The invention provides application of a nitrothiazole derivative in preparation of a bacteriostatic agent for inhibiting helicobacter pylori, and belongs to the field of pharmacy. The structure of the aminonitrothiazole derivative is shown as a formula I in the specification. Experimental results sh...

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Bibliographische Detailangaben
Hauptverfasser: YANG TAI, LIU JIN, HUANG SHENG, PENG XIANGYANG, GUANG BING, ZHAN WEI, LAI YONGXIN, XU QING, DONG RENHAN, QIN CHUANJUN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides application of a nitrothiazole derivative in preparation of a bacteriostatic agent for inhibiting helicobacter pylori, and belongs to the field of pharmacy. The structure of the aminonitrothiazole derivative is shown as a formula I in the specification. Experimental results show that the compound can effectively inhibit the growth of helicobacter pylori, and the inhibition effect is better than that of contrast compounds nitazoxanide and lauric acid; the compound can be used for effectively treating mice infected by helicobacter pylori, removing the helicobacter pylori infected by the stomach and reducing the inflammatory response of the stomach tissue, and the treatment effect of the compound is superior to that of contrast compounds, namely nitazoxanide and lauric acid. The compound provided by the invention can be used for preparing a bacteriostatic agent for inhibiting helicobacter pylori, can be used for preparing medicines for preventing and/or treating helicobacter pylori infecti