Fully human bispecific antibody for resisting new coronavirus variant

The invention discloses a fully human bispecific neutralizing antibody capable of resisting new coronavirus. The fully human bispecific neutralizing antibody is formed by modifying two strains of fully human neutralizing antibodies of new coronavirus. According to the present invention, the antibody can effectively neutralize the current popular Omicro sub-variants such as BF.7, BA.5, XBB.1. 5, BQ.1. 1 and CH.1. 1, wherein the Omicro sub-variants have strong escape ability; compared with a parent monoclonal antibody and cocktail strategy, the bispecific antibody disclosed by the invention has stronger antiviral activity and escape mutation inhibition capability, is a feasible and effective strategy for treating and preventing severe new coronavirus, and has the potential to become a candidate drug for intervening the new coronavirus. 本发明公开了一种可以抗新冠病毒的全人源双特异性中和抗体，其由两株新冠病毒全人源中和性抗体改构而成。所述抗体能够有效中和目前流行的具有强逃逸能力的Omicron亚变种BF.7、BA.5、XBB.1.5、BQ.1.1和CH.1.1。相较于亲本单抗及鸡尾酒策略，本发明公开的双特异性抗体具有更强的抗病毒活性和抑制逃逸突变的能力，是治疗和预防重症新冠病毒的一种可行