Alpha-trifluoromethyl diazonium sulfonium salt compound and application thereof
The invention discloses an alpha-trifluoromethyl diazonium sulfonium salt compound and application thereof, and belongs to the technical field of organic synthesis. The structural formula of the alpha-trifluoromethyl diazonium sulfonium salt compound is # imgabs0, and the alpha-trifluoromethyl diazo...
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Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses an alpha-trifluoromethyl diazonium sulfonium salt compound and application thereof, and belongs to the technical field of organic synthesis. The structural formula of the alpha-trifluoromethyl diazonium sulfonium salt compound is # imgabs0, and the alpha-trifluoromethyl diazonium sulfonium salt compound is obtained by mixing and reacting a hypervalent iodine reagent, thioether and an organic solvent. An organic solvent, a rhodium catalyst, N-heteroaromatic hydrocarbon, a nitrile compound, alkali and the alpha-trifluoromethyl diazonium sulfonium salt compound are mixed, [2 + 1 + 2] series cyclization reaction is carried out, and the imidazo N-heteroaromatic hydrocarbon compound is obtained.The research finds that the compound has certain activity of inhibiting tumor cell growth, can be expected to be used as an anti-tumor medicine, and can be applied to preparation of antitumor drugs. And a basis is provided for research of the imidazo N-heteroaromatic skeleton polycyclic compound in th |
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